CDDI Members by Research Interests

Molecular Targets and Pharmacology

Cancer Research

Molecular Biophysics and Structural Biology

Computation and Informatics

  • Gaasterland, Terry

    Integrate, analyze, and visualize the output of high throughput molecular biology experiments in the context of complete genome sequence data.
  • Iakoucheva, Lilia

    Understand how seemingly unrelated candidate genes contribute to psychiatric diseases, such as autism and schizophrenia by building disease-focused protein-protein interaction networks using experimental (yeast two-hybrid) and computational approaches.

    Representative publications:
    1) Neuron. 85(4):742-54., 2015
    2) Cell. 159(5):1212-26., 2014

  • Ideker, Trey

    Use genome-scale measurements (genomic, proteomic, and metabolomic) to assemble network models of cellular processes and disease.
  • McCulloch, Andrew

    Use experimental and computational models to investigate the relationships between the cellular and extracellular structure of cardiac muscle and the electrical and mechanical function of the whole heart during ventricular remodeling, heart failure and arrhythmia.

    Therapeutic area(s): Heart failure, Cardiac arrhythmias, Ischemic heart disease
    Technology area(s): Multi-scale computational modeling, Systems biology, In-vivo and in-vitro biophysics and physiology

    Representative publications:
    1) J. Clin. Invest. 122(4):1209-21., 2012
    2) Prog. Biophys. Mol. Biol. 107(1):147-55., 2011
    3) BMC Syst. Biol. 3:91., 2009

  • Ohno-Machado, Lucila

    iDASH: integrating Data for Analysis, Anonymization, and Sharing, SCANNER: SCAlable National Network for Effectiveness Research, Validation of Breast Cancer Biomarkers.
  • Palsson, Bernhard

    Reconstruction of genome-scale biochemical reaction networks (metabolism, transcriptional regulation & signaling) and the development of mathematical analysis procedures for genome-scale models.
  • Pevzner, Pavel

    Computational proteomics, next generation DNA sequencing, genome rearrangements, pattern discovery, and comparitive proteogenomics.
  • Smarr, Larry

    Development of major cyberinfrastructure projects including Camera, Optiputer, and the GreenLight Project.
  • Subramaniam, Shankar

    Development of applications for genome annotation, protein fold prediction, functional genomics, and reconstruction and modeling of biochemical pathways.

Synthesis, Natural Products, Biologics, Materials

Drug Disposition and Delivery

Translational and Clinical

  • Calcutt, Nigel

    Therapies for peripheral neuropathy and neuropathic pain.

    Therapeutic area(s): Peripheral neuropathies, Pain, Nerve regeneration
    Technology area(s): Corneal confocal microscopy, Animal models of neuropathy

    Representative publications:
    1) J. Clin. Invest. 127(2):608-622, 2017
    2) Nat. Rev. Drug Discov. 8(5):417-29., 2009
  • Chao, Daniel

    Development of new therapeutics for retinal vascular diseases such as diabetic retinopathy and macular degeneration, using high throughput small molecule screens in zebrafish embryos

    Therapeutic area(s): Opthalmology, Angiogenesis
    Technology area(s): Whole organism HTS screening using zebrafish, Automated high content imaging analyses

  • Dugan, Laura

    Characterize the role of free radicals, oxidative stress and the more subtle effects of free radicals on intracellular signaling cascades in aging brain; rationally-designed buckminsterfullerene derivatives as antioxidants and neuroprotective agents.
  • Mackey, Tim K.

    Drug discovery policy, law, intellectual property, and governance including assessing policy mechanisms that increase equitable access to biomedical innovations.

    Technology area(s): Open drug discovery platforms, Intellectual property, Interest in innovation for neglected tropical diseases

    Representative publications:
    1) Clin. Microbiol. Rev. 27(4):949-979., 2014
    2) PLoS One. 7(11):e51022., 2012
    3) Drug Discov. Today. 17(23-24):1254-1257., 2012

  • Mehta, Ravindra

    Compare different dialytic modalities in the treatment of acute kidney injury (AKI), evaluate different predictive models for outcomes in AKI, investigate the role of cytokine removal by dialysis membranes in sepsis and AKI, and evaluate techniques for determining the amount of excess fluid in dialysis patients.
  • Muotri, Alysson

    To generate in vitro models from induced pluripotent stem cells for the understanding and treatment of neurological genetic diseases, such as autism spectrum disorders. Cerebral organoids can be generated and engineered for drug screening purposes.

    Technology area(s): Brain organoids, Genome editing, Drug screening

    Representative publications:
    1) Nature. 536(7616):338-43., 2016
    2) Mol. Psychiatry., doi: 10.1038/mp.2016.95., 2016
    3) Nature. 534(7606):267-71., 2016

  • Vinetz, Joseph

    Molecular, cellular and biochemical mechanisms by which the malaria parasite (the ookinete) stage invades the mosquito midgut; molecular and genetic changes aspects of Leptospira and the human host response in leptospirosis predisposing to severe disease.